The non-invasive IVDD cleared obstructive coronary artery disease test
Validated in three clinical studies, Cardio Explorer® helps identify low-risk patients – without radiation or contrast agents.
Cardio Explorer® is certified and trusted by clinical institutions
Watch video
2 min

The effectiveness and safety of Cardio Explorer® has been demonstrated across 3 peer-reviewed clinical studies.

4 out of 100 patients are incorrectly identified as not having obstructive CAD
when selecting low- and very-low-risk patients for rule-out

How the Cardio Explorer® works

Cardio Explorer® uses an AI-enhanced algorithm to assess each patient’s clinical likelihood of obstructive coronary artery disease by analyzing blood biomarkers, ECG data, symptoms, and clinical risk factors.

The result supports clinical decision-making by indicating whether further cardiac evaluation is warranted.

Patient data can be entered manually or seamlessly synced through our API for automated analysis.

Symptoms & history
Collected during consultation. Includes chest pain characteristics, smoking status, and ECG findings.
Clinical parameters & medications
Entered by the physician or imported from the record. Includes blood pressure, BMI, diabetes therapy, and prescribed medications such as statins and antihypertensives.
Blood panel
Uploaded from lab systems or entered manually. Includes key biomarkers such as Hs-troponin T, cholesterol, and liver function markers.

A safer alternative to imaging

Cardio Explorer is a non-invasive diagnostic option for patients who prefer or need to ensure:
No ionising radiation
No contrast agents
No enclosed imaging environments
Certified for use as a pre-test for obstructive CAD in the EU and UK.

Suitable patient profiles

Cardio Explorer is suitable for patients presenting with stable symptoms or risk factors suggestive of Chronic Coronary Syndrome (CCS), such as:
Chest pain
Exertional dyspnea
Unexplained fatigue
Atypical pain

Asymtopatic, but high-risk patients

Risk factors: Heart failure or left ventricular dysfunction, atherosclerotic disease in other vascular terrotories, metabolic syndrome, diabetes, hypertension, smoking, dyslipidemia, COPD and strong family history.
When Cardio Explorer is not appropriate
Cardio Explorer is not intended for use in patients who have known CAD or are suspected of having acute coronary artery disease.

How Cardio Explorer® fits into guideline-based care

Cardio Explorer helps standardize care by embedding evidence-based guidelines directly into your diagnostic workflow.

Cardio Explorer can be used to calculate the clinical likelihood in guideline-based care:
1. Clinical examination
2. If rule in, further evaluation using Cardio Explorer
3. Confirming the diagnosis with further testing based on the clinical likelihood
4. Treatment if needed

Variability in early CCS workup can delay diagnosis or lead to overtesting. Cardio Explorer aligns with clinical guidelines to ensure consistent, high-quality care — every time.

Diagnostic accuracy comparison for obstructive coronary artery disease detection

All algorithms achieve an NPV above 95%; Cardio Explorer combines this with superior diagnostic accuracy (AUC 87%) and high sensitivity at a low false positive rate. Among available algorithms, Cardio Explorer is uniquely suited to support screening for chronic coronary syndrome.

How Cardio Explorer compares with other pre-test diagnostics

Meet the Cardio Explorer® medical advisory board

Prof. Michael Zellweger
Prof. Michael Zellweger
Head of Non-Invasive Cardiology, University Hospital Basel
DEtails
Prof. Hans-Peter Brunner-La Rocca
Prof. Hans-Peter Brunner-La Rocca
Vice Chairman, Department of Cardiology, Maastricht University Medical Centre (MUMC+)
DEtails
Evidence
Our in-house Medical & Research team has contributed to over 3 peer-reviewed publications focused on the development and validation of Cardio Explorer®. These studies support the test’s accuracy, safety, and clinical utility in assessing clinical likelihood of obstructive CAD across diverse patient populations.
Clinical resources
Download printable clinical resources
ESC medical guidelines on suspected chronic coronary syndrome
Download
Instructions for use
Download

Frequently asked questions

Why is the rule-out threshold different from the ESC 2024 algorithms?

The appropriate rule-out threshold or probability depends on an algorithm’s accuracy. Cardio Explorer achieves a negative predictive value (NPV) greater than 95% at a threshold of 15%, whereas the ESC 2024 algorithm only reaches the required rule-out accuracy at a threshold of 5%.

Speak with a cardiology expert
We welcome questions from clinicians, researchers, and partners. Whether you're exploring clinical use, seeking technical integration support, proposing an investigator-initiated study, or evaluating broader collaboration opportunities, our medical team is here to help.
Michael Zellweger
Prof. Michael Zellweger
Head of Non-Invasive Cardiology, University Hospital Basel
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